Repairing injured peripheral nerves: Bridging the gap (2025)

Deumens, R., Bozkurt, A., Meek, M. F., Marcus, M. A. E., Joosten, E. A. J., Weis, J., & Brook, G. A. (2010). Repairing injured peripheral nerves: Bridging the gap. Progress in Neurobiology, 92(3), 245-276. https://doi.org/10.1016/j.pneurobio.2010.10.002

Deumens, Ronald ; Bozkurt, Ahmet ; Meek, Marcel F. et al. / Repairing injured peripheral nerves: Bridging the gap. In: Progress in Neurobiology. 2010 ; Vol. 92, No. 3. pp. 245-276.

@article{bccde276bb70401d8f50e1979eb2a1ae,

title = "Repairing injured peripheral nerves: Bridging the gap",

abstract = "Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries. ",

keywords = "Axon regeneration, Peripheral nerve injury, Nerve grafting, Autologous nerves, Neurodegeneration, Neuropathic pain, Nerve guides, Nerve repair",

author = "Ronald Deumens and Ahmet Bozkurt and Meek, {Marcel F.} and Marcus, {Marco A. E.} and Joosten, {Elbert A. J.} and Joachim Weis and Brook, {Gary A.}",

year = "2010",

month = nov,

doi = "10.1016/j.pneurobio.2010.10.002",

language = "English",

volume = "92",

pages = "245--276",

journal = "Progress in Neurobiology",

issn = "0301-0082",

publisher = "Elsevier Science",

number = "3",

}

Deumens, R, Bozkurt, A, Meek, MF, Marcus, MAE, Joosten, EAJ, Weis, J & Brook, GA 2010, 'Repairing injured peripheral nerves: Bridging the gap', Progress in Neurobiology, vol. 92, no. 3, pp. 245-276. https://doi.org/10.1016/j.pneurobio.2010.10.002

Repairing injured peripheral nerves: Bridging the gap. / Deumens, Ronald; Bozkurt, Ahmet; Meek, Marcel F. et al.
In: Progress in Neurobiology, Vol. 92, No. 3, 11.2010, p. 245-276.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Repairing injured peripheral nerves: Bridging the gap

AU - Deumens, Ronald

AU - Bozkurt, Ahmet

AU - Meek, Marcel F.

AU - Marcus, Marco A. E.

AU - Joosten, Elbert A. J.

AU - Weis, Joachim

AU - Brook, Gary A.

PY - 2010/11

Y1 - 2010/11

N2 - Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries.

AB - Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries.

KW - Axon regeneration

KW - Peripheral nerve injury

KW - Nerve grafting

KW - Autologous nerves

KW - Neurodegeneration

KW - Neuropathic pain

KW - Nerve guides

KW - Nerve repair

U2 - 10.1016/j.pneurobio.2010.10.002

DO - 10.1016/j.pneurobio.2010.10.002

M3 - Article

C2 - 20950667

SN - 0301-0082

VL - 92

SP - 245

EP - 276

JO - Progress in Neurobiology

JF - Progress in Neurobiology

IS - 3

ER -

Deumens R, Bozkurt A, Meek MF, Marcus MAE, Joosten EAJ, Weis J et al. Repairing injured peripheral nerves: Bridging the gap. Progress in Neurobiology. 2010 Nov;92(3):245-276. doi: 10.1016/j.pneurobio.2010.10.002